Antiviral Chemotherapy: Design or Serendipity ?
作者： R. T. Walker
DOI: 10.1007/978-94-009-3353-8_4
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摘要: There are currently in the world, and particularly Belgium, many people who owe their good eyesight some cases, even lives, to decision made by Professor Piet De Somer that work being done Prof. Erik Clercq at Rega Institute on antiviral chemotherapy was worth supporting discoveries should be exploited. From this joint research involving chemists United Kingdom, and, more recently, those Institute, together with expertise other areas from several laboratories around has arisen compound BVDU [(E)-5-(2-bromovinyl)-2′-deoxyuridine] (1), most potent member of an ever-growing family 5-vinylpyrimidine-2′-deoxynucleo-sides which exhibit anti-herpesvirus activity (2).
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sci-hub.st 参考文章(24)
J. S. Oxford, Anti Influenza Virus Activity of Amantadine, Rimantadine and Analogues Springer, Boston, MA. pp. 159- 176 ,(1984) , 10.1007/978-1-4684-4709-5_7
Targets for the design of antiviral agents Published in cooperation with NATO Scientific Affairs Division [by] Plenum Press. ,(1984) , 10.1007/978-1-4684-4709-5
E. De Clercq, R.T. Walker, Chemotherapeutic agents for herpesvirus infections. Progress in Medicinal Chemistry. ,vol. 23, pp. 187- 218 ,(1986) , 10.1016/S0079-6468(08)70343-6
A.J. Hay, A.J. Wolstenholme, J.J. Skehel, M.H. Smith, The molecular basis of the specific anti-influenza action of amantadine. The EMBO Journal. ,vol. 4, pp. 3021- 3024 ,(1985) , 10.1002/J.1460-2075.1985.TB04038.X
Erik De Clercq, Antonin Holý, Ivan Rosenberg, Takashi Sakuma, Jan Balzarini, Parbhat C. Maudgal, A novel selective broad-spectrum anti-DNA virus agent. Nature. ,vol. 323, pp. 464- 467 ,(1986) , 10.1038/323464A0
Erik De Clercq, Richard T. Walker, Synthesis and antiviral properties of 5-vinylpyrimidine nucleoside analogs. Pharmacology & Therapeutics. ,vol. 26, pp. 1- 44 ,(1984) , 10.1016/0163-7258(84)90049-4
C. Desgranges, G. Razaka, M. Rabaud, H. Bricaud, J. Balzarini, E. de Clercq, Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets. Biochemical Pharmacology. ,vol. 32, pp. 3583- 3590 ,(1983) , 10.1016/0006-2952(83)90307-6
Erik De Clercq, Claude Desgranges, Piet Herdewijn, Iain S. Sim, A. Stanley Jones, Michael J. McLean, Richard T. Walker, Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine. Journal of Medicinal Chemistry. ,vol. 29, pp. 213- 217 ,(1986) , 10.1021/JM00152A008
J J Cassiman, E De Clercq, A S Jones, R T Walker, H Van den Berghe, Sister chromatid exchange induced by anti-herpes drugs. BMJ. ,vol. 283, pp. 817- 818 ,(1981) , 10.1136/BMJ.283.6295.817
R.T. Walker, P.J. Barr, A.S. Jones, Incorporation of 5-substituted uracil derivatives into nucleic acids. Part IV. The synthesis of 5-ethynyluracil. Nucleic Acids Research. ,vol. 3, pp. 2845- 2850 ,(1976) , 10.1093/NAR/3.10.2845