High Fat Diet Affects The Dopamine Reward System: Importance Of Sex And Critical Developmental Periods

摘要: Obesity is a costly and growing health concern for the modern world puts individuals at increased risk chronic illnesses. Although obesity associated with many detrimental peripheral effects, food over consumption centrally mediated. The hypothalamus brainstem regions control homeostatic intake, while hedonic intake mainly controlled by central reward system. Palatable foods are rewarding ride system cause consumption. Foods high in sugar fat acutely activate dopamine neurons classical pathway consisting of ventral tegmental area projecting to nucleus accumbens prefrontal cortex. Chronic palatable neuroadaptations that can lead behavioral changes further This dissertation characterizes behavioral, transcriptional, circuitry after diet withdrawal male female mice. Four models diet-induced were examined. Chapters 2 3 examined induced standard chow intervention different age groups order reveal developmental period sensitive programming effects. We discovered both sex critical factors development reversal seen obesity. Early life nutrition particularly important developing brain overnutrition during this time leads epigenetic may contribute persist intervention. In chapter 4, we exercise as an prevent neuroinflammation intake. although had beneficial effect weight gain, it was not able reverse dysfunction or all cases It possible occur difficulty have loss. Understanding how impact behavior stage will implication management interventions. know now individual markedly than lean these differences predispose one overconsumption dietary Since pharmacological therapies often combined replacement, understanding switch raise adherence rates help success future. Degree Type Dissertation Name Doctor Philosophy (PhD) Graduate Group Pharmacology First Advisor Teresa M. Reyes available ScholarlyCommons: http://repository.upenn.edu/edissertations/1226