Expression and modulatory effects of heme oxygenase in acute inflammation in the rat.
作者： D. Willis
DOI: 10.1007/BF01778342
关键词:
摘要: Heme oxygenase (HO) is the rate limiting enzyme in catabolism of heme molecules to bile pigments which have recently been demonstrated be strong antioxidants. In this study we analyzed activity HO inflammatory cells isolated from a model carrageenin induced acute inflammation rat. was significantly higher 24 hours after induction inflammation, increase coincided with appearance highly inducible isoform HO, Heat Shock Protein 32 kDa (HSP32) as detected by Western Blot analysis. Pre-treatment animals Tin protoporphyrin, inhibitor, increased cell exudate at hour 128% compared vehicle control. comparison pre-treatment inducer, Ferriprotoporphyrin, decreased number 50% and 73% These results suggest that may represent an endogenous protective mechanism against free radicals involved resolution inflammation. The HSP32 therefore novel therapeutic target for modulation response.
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