High numerical aperture microendoscope objective for a fiber confocal reflectance microscope

作者: Robert T. Kester , Tomasz S. Tkaczyk , Michael R. Descour , Todd Christenson , Rebecca Richards-Kortum

DOI: 10.1364/OE.15.002409

关键词:

摘要: A disposable high numerical aperture microendoscope objective has been designed, fabricated, and tested for use with a fiber confocal reflectance microscope. The uses precision LIGA fabricated components to integrate imaging hydraulic suction lines into housing that measures only 3.85 mm in outer diameter 14.65 length. hydraulics are used translate tissue through the focal plane three dimensional imaging. This device is diffraction limited λ = 850 nm, of 1.0, field view 250 μm, working distance 450 μm. intended vivo precancerous cells.

参考文章(10)
Alex W. H. Lin, Nastassja A. Lewinski, Jennifer L. West, Naomi J. Halas, Rebekah A. Drezek, Optically tunable nanoparticle contrast agents for early cancer detection: model-based analysis of gold nanoshells Journal of Biomedical Optics. ,vol. 10, pp. 064035- ,(2005) , 10.1117/1.2141825
Chen Liang, Michael Descour, Kung-Bin Sung, Rebecca Richards-Kortum, Fiber confocal reflectance microscope (FCRM) for in-vivo imaging Optics Express. ,vol. 9, pp. 821- 830 ,(2001) , 10.1364/OE.9.000821
Matthew D Chidley, Kristen D Carlson, Rebecca R Richards-Kortum, Michael R Descour, None, Design, assembly, and optical bench testing of a high-numerical-aperture miniature injection-molded objective for fiber-optic confocal reflectance microscopy Applied Optics. ,vol. 45, pp. 2545- 2554 ,(2006) , 10.1364/AO.45.002545
Matthew D. Chidley, Chen Liang, Michael R. Descour, Kung-Bin Sung, Rebecca R. Richards-Kortum, Ann Gillenwater, Miniature injection-molded optics for fiber optic in vivo confocal microscopy Proceedings of SPIE - The International Society for Optical Engineering. ,vol. 4832, pp. 126- 136 ,(2002) , 10.1117/12.486426
Christopher Loo, Leon Hirsch, Min-Ho Lee, Emmanuel Chang, Jennifer West, Naomi Halas, Rebekah Drezek, Gold nanoshell bioconjugates for molecular imaging in living cells. Optics Letters. ,vol. 30, pp. 1012- 1014 ,(2005) , 10.1364/OL.30.001012
Xiaohua Huang, Ivan H. El-Sayed, Wei Qian, Mostafa A. El-Sayed, Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods Journal of the American Chemical Society. ,vol. 128, pp. 2115- 2120 ,(2006) , 10.1021/JA057254A
Peter D. Burns, Slanted-Edge MTF for Digital Camera and Scanner Analysis PICS. pp. 135- 138 ,(2000)
Chen Liang, Kung-Bin Sung, Rebecca R. Richards-Kortum, Michael R. Descour, Design of a high-numerical-aperture miniature microscope objective for an endoscopic fiber confocal reflectance microscope. Applied Optics. ,vol. 41, pp. 4603- 4610 ,(2002) , 10.1364/AO.41.004603