Beneficial effect of cyclosporine A on traumatic hemorrhagic shock.

摘要: Abstract Background Vascular hyporeactivity plays an important role in severe trauma and shock. We investigated the beneficial effect of cyclosporine A (CsA) on traumatic shock its relationship to vascular reactivity improvement mitochondrial permeability transition pore (MPTP). Materials methods Sodium pentobarbital-anesthetized rats were used induce hemorrhagic by left femur fracture hemorrhage, effects CsA (1, 5, 10 mg/kg, intravenously) animal survival, cardiovascular function, tissue blood perfusion, function vital organs observed. In addition, hypoxia-treated smooth muscle cells from normal investigate this Rho-associated serine/threonine kinase (ROCK) protein C. Results prolonged survival time increased 24-h rate (31%, 56%, 56% 1, 10 mg/kg group versus 25% lactated Ringer solution group). Five milligrams per kilogram had best effect, which stabilized improved hemodynamics, flow, liver kidney including rats. no significant influences production inflammatory mediators cardiac output after Further results indicated that significantly constriction dilation superior mesenteric artery norepinephrine acetylcholine, was antagonized ROCK inhibitor, Y27632, but not C staurosporine. studies showed restored hypoxia-induced decrease activity inhibited opening MPTP cells. Conclusions is for treatment The mechanism mainly through improving reactivity, stabilizing increasing perfusion. This related inhibitory opening. regulator molecule process.