Factors influencing survival after gamma knife radiosurgery for patients with single and multiple brain metastases.

摘要: PURPOSE Radiosurgery has been reported to yield high local control rates for brain metastases. However, further work is needed define which subgroups of patients may benefit from this treatment modality. PATIENTS AND METHODS We reviewed 116 who underwent stereotactic radiosurgery initial management or recurrence solitary multiple metastases September 1991 through December 1994 at the University California, San Francisco. Survival time and local-regional failure were calculated using Kaplan-Meier method. Univariate multivariate analyses performed Cox proportional hazards model. RESULTS Median survival was 40 weeks radiosurgery. In analysis, smaller total tumor volume, absence extracranial metastases, higher Karnofsky score, age < = 70 had a positive effect on survival. initially managed addition whole radiotherapy no significant Although presence associated with significantly worse rate in univariate it not as factor analysis. An analysis within series treated would have eligible Patchell's study role surgery metastasis revealed favorable median weeks. CONCLUSIONS conclude that radiosurgical results times compare favorably historic experience alone surgical resection. presenting equivalent radiotherapy, but intracranial quality life also need be evaluated. Also, should contraindication use given good achieved such series. Each case therefore evaluated based other factors patient's age, score systemic disease.