Boron-containing peptidomimetics--a novel class of selective anti-tubercular drugs.
作者： Alexey S. Gorovoy , Olga V. Gozhina , John S. Svendsen , Anna A. Domorad , George V. Tetz
DOI: 10.1111/CBDD.12091
关键词:
摘要: Medical treatment for tuberculosis is complicated nowadays by the appearance of new multiresistant strains, and therefore, antibiotics are in great need. Here, we report synthesis vitro testing a class highly selective antimicrobial boron-containing peptidomimetics with compounds exhibiting activity against Mycobacterium at ≤5 μg/mL. The approach developed makes it possible to synthesize variously substituted β-aminoboronic acids their derivatives high level diastereoselectivity.
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