Benefits and Risks of Colorectal Cancer Screening

摘要: sary diagnostic and therapeutic steps of all examination modalities, the indications for general CRC screening, risk situations, as well necessary follow-up intervals after diagnosis resection [4]. In most cases, develops via precursor lesions, socalled polyps or adenomas, progression which through accumulation genetic changes is known (adenomacancer sequence). An important fact that these tumors grow slowly over 10–15 years, because this time frame due to process growth into lumen gut, they can be easily detected fecal analysis (occult blood test) by endoscopy (colonoscopy) with possibility immediate lesions early cancers. Recent investigations have demonstrated especially in right-sided colon there are subgroups polyps, so-called serrated faster [5]. Since 2002 Germany, an enhanced but still opportunistic prevention detection program exists both sexes, includes guaiac-based occult test (gFOBT) beginning 50th year age screening colonoscopy 55th age. The stool offered annually up year, case refusal every 2 years 56th year. Screening repeated 10 inconspicuous initial colonoscopy. basis implementation validation gFOBT was formed a number large randomized studies long-term highest evidence level 1A. According studies, it accepted annual biennial use significant reduction incidence approximately 20% achieved [6–8]. Colorectal Cancer Screening: Pro Jurgen F. Riemann (Ludwigshafen)