C/EBPbeta is over-expressed in gastric carcinogenesis and is associated with COX-2 expression.
作者： G Regalo , P Canedo , G Suriano , C Resende , ML Campos
DOI: 10.1002/PATH.2063
关键词:
摘要: The CCAAT/enhancer-binding protein beta (C/EBPbeta) transcription factor has been associated with several cancer models. In this study, the expression of C/EBPbeta was analysed in a series 90 gastric carcinomas (GCs). We also assessed effect on COX-2 expression. normal mucosa, restricted to cells proliferative zone. intestinal metaplasia, dysplasia, and GC atypical subtypes, over-expressed (p < 0.0001, for association histological type). Ki67, marker cell proliferation, were co-expressed primary GC. observed an overlap between Using lines we show that can regulate endogenous transactivate promoter gene, depending its methylation status. These results suggest may be neoplastic transformation play active role tumourigenesis by regulating
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