Rodents for comparative aging studies: from mice to beavers.
作者： Vera Gorbunova , Michael J. Bozzella , Andrei Seluanov
DOI: 10.1007/S11357-008-9053-4
关键词:
摘要: After humans, mice are the best-studied mammalian species in terms of their biology and genetics. Gerontological research has used rats extensively to generate short- long-lived mutants, study caloric restriction more. Mice valuable model organisms thanks small size, short lifespans fast reproduction. However, when goal is further extend already long human lifespan, studying aging may not provide all answers. Remarkably, addition fast-aging species, order Rodentia contains multiple with exceeding 20 years (naked mole-rat, beavers, porcupines, some squirrels). This diversity opens great opportunities for comparative studies. Here we discuss evolution lifespan rodents, review slow-aging show an example how use a approach revealed that telomerase activity coevolved body mass rodents.
springer.com
paperity.org
researchgate.net 参考文章(40)
A.M. Olovnikov, A theory of marginotomy: The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon Journal of Theoretical Biology. ,vol. 41, pp. 181- 190 ,(1973) , 10.1016/0022-5193(73)90198-7
Bernhard Grzimek, Grzimek's Animal Life Encyclopedia ,(1984)
Jerry W. Shay, Woodring E. Wright, Hayflick, his limit, and cellular ageing Nature Reviews Molecular Cell Biology. ,vol. 1, pp. 72- 76 ,(2000) , 10.1038/35036093
L.J. Anthony, The New Encyclopedia of Mammals Reference Reviews. ,vol. 16, pp. 23- 23 ,(2002) , 10.1108/RR.2002.16.5.23.248
Woodring E. Wright, Jerry W. Shay, Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nature Medicine. ,vol. 6, pp. 849- 851 ,(2000) , 10.1038/78592
Andrzej Bartke, Holly Brown-Borg, Life extension in the dwarf mouse. Current Topics in Developmental Biology. ,vol. 63, pp. 189- 225 ,(2004) , 10.1016/S0070-2153(04)63006-7
Ronald M. Nowak, Ernest P. Walker, Walker's mammals of the world ,(1968)
Anna Csiszar, Nazar Labinskyy, Xiangmin Zhao, Furong Hu, Sabrina Serpillon, Zhishan Huang, Praveen Ballabh, Richard J. Levy, Thomas H. Hintze, Michael S. Wolin, Steven N. Austad, Andrej Podlutsky, Zoltan Ungvari, Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity. Aging Cell. ,vol. 6, pp. 783- 797 ,(2007) , 10.1111/J.1474-9726.2007.00339.X
William J. Murphy, Eduardo Eizirik, Warren E. Johnson, Ya Ping Zhang, Oliver A. Ryder, Stephen J. O'Brien, Molecular phylogenetics and the origins of placental mammals Nature. ,vol. 409, pp. 614- 618 ,(2001) , 10.1038/35054550
Thomas B. L. Kirkwood, Steven N. Austad, Why do we age Nature. ,vol. 408, pp. 233- 238 ,(2000) , 10.1038/35041682