Peptide and carbohydrate complexes of nickel in human kidney.

摘要: The predominant renal and urinary forms of nickel consist low-Mr complexes. Similarities in the nature these complexes have been found kidneys rats exposed parenterally to NiCl2 rat treated with vitro. Similar also identified after treatment bovine human soluble fractions NiCl2. bulk all cases is associated sulphated oligosaccharide containing uronic acids neutral sugars. This binding non-specific, readily displaced from by copper. Smaller amounts are bound an acidic peptide, which was purified partially characterized. Nickel not this material copper at physiological pH. These plasma, suggesting that ligand exchange occurs during or glomerular filtration metal.