TAS2R38 Bitterness Receptor Genetic Variation and Risk of Gastrointestinal Neoplasm: A Meta-Analysis

摘要: Genetic variation in TAS2R38 bitterness taste receptor could alter the efficacy of molecular sensing, hence may be associated with cancer risk. Thus, we performed a meta-analysis to verify association between risk gastrointestinal (GI) neoplasm and genetic variation. Studies diplotype distribution GI phenotypes were searched from PubMed, EMBASE SCOPUS, five articles including eight studies finally selected. The was estimated summarized odds ratios (ORs) 95% confidence intervals (CIs), applying fixed- or random-effects models. findings suggested not neoplasms susceptibility [AVI vs. PAV: OR = 1.03 (95%CI: 0.97-1.09), AVI/PAV PAV/PAV: 1.05, 0.94-1.17), AVI/* 1.04 0.94-1.16)]. Because presence heterogeneity under two models (AVI/AVI PAV/PAV AVI/AVI PAV/*), further subgroup analyses by ethnicity type performed. However, results failed show altered diplotype. In conclusion, indicates that minimally modified Given limited study size resources, well-designed larger are required validate true effect polymorphisms on