Automated determination of metastases in unstructured radiology reports for eligibility screening in oncology clinical trials.

摘要: Enrolling adequate numbers of patients that meet protocol eligibility criteria in a timely manner is critical, yet clinical trial accrual continues to be problematic. One approach these challenges utilize technology automatically screen for eligibility. This manuscript reports on the evaluation different automated approaches determine metastatic status from unstructured radiology using Clinical Trials Eligibility Database Integrated System (CTED). The study sample included all (N = 5,523) with radiologic diagnostic studies (N = 10,492) completed two-week period. Eight search algorithms (queries) within CTED were developed and applied reports. performance each algorithm was compared reference standard which consisted physician’s review Sensitivity, specificity, positive, negative predicted values calculated algorithm. number identifie...