Melatonin and tumeric ameliorate aging-induced changes: implication of immunoglobulins, cytokines, DJ-1/NRF2 and apoptosis regulation.
作者： Hanan A El-Bakry , Ismail Ahmed Ismail , Ismail Ahmed Ismail , Safaa S Soliman
DOI:
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摘要: Aging is associated with several biological, physiological, cellular and histological changes. In the present study, we investigated effect of aging on different signaling pathways, including antioxidant system, apoptosis immune status. Several natural products were used to ameliorate block aging-related Melatonin turmeric have been known decrease However, exact mechanism(s) their action not fully understood. tried uncover regulatory by which melatonin work against aging. We found that differentially regulated blood serum immunoglobulins; increased IgA decreased IgE. Furthermore, all cytokines (TNF-α, IFN-γ, IL-6 IL-8) highly addition, upstream regulators; DJ-1 NRF2 markedly repressed in thymus tissues. also induced promoting genes p53 Bax mRNA Finally, clear changes spleen Administration either or tumeric clearly ameliorated blocked some extinct Altogether, was downregulation NRF2, promoted reversed through activating DJ-1/NRF2 pathway inhibiting p53/Bax apoptotic pathway.
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