Deregulated microRNAs in multiple myeloma

摘要: MicroRNAs are short noncoding RNAS involved in gene expression regulation under physiological and pathological situations. They bind to mRNA of target genes potential regulators at a post-transcription level through the RNA interference pathway. estimated represent 1% 2% known eukaryotic genome, it has been demonstrated that they pathogenesis neurodegenerative diseases, cancer, metabolism disorders, heart disease. act as tumor suppressors or oncogenes cancer biology. The authors describe current knowledge on microRNA involvement regulatory pathways characterize multiple myeloma gained from vitro vivo studies. These small molecules interact with important factors such p53, SOCS1, IGF-1, IGF-1R, vascular endothelial growth factor, NF-κB, others. As such, microRNAs an attractive therapeutic context interfering networks. Further studies needed better understand their role myelomagenesis potential. Cancer 2012;. © 2011 American Society.