Biologically improved nanofibrous scaffolds for cardiac tissue engineering.

摘要: Nanofibrous structure developed by electrospinning technology provides attractive extracellular matrix conditions for the anchorage, migration and differentiation of stem cells, including those responsible regenerative medicine. Recently, biocomposite nanofibers consisting two or more polymeric blends are electrospun tidily in order to obtain scaffolds with desired functional mechanical properties depending on their applications. The study focuses one such an attempt using copolymer Poly(l-lactic acid)-co-poly (e-caprolactone) (PLACL), silk fibroin (SF) Aloe Vera (AV) fabricating nanofibrous cardiac tissue engineering. SEM micrographs fabricated PLACL, PLACL/SF PLACL/SF/AV porous, beadless, uniform interconnected pores obtained fibre diameter range 459 ± 22 nm, 202 12 nm 188 16 respectively. mats at room temperature elastic modulus 14.1 0.7, 9.96 2.5 7.0 0.9 MPa have desirable act as flexible cell supporting compared PLACL repair myocardial infarction (MI). had a contact angle 51 12° that 133 15° alone. Cardiac proliferation was increased 21% day 6 further 42% 9. Confocal analysis expression proteins myosin connexin 43 observed better 9 all other scaffolds. results proved good potentiality regeneration infarcted myocardium