Nonlinear and frequency-dependent mechanical behavior of the mouse respiratory system.

摘要: The assessment of the mechanical properties respiratory system is typically done by oscillating flow into lungs via trachea, measuring resulting pressure generated at and relating two signals to each other in terms some suitable mathematical model. If perturbing signal broadband not too large amplitude, linear behavior usually assumed input impedance calculated. Alternatively, researchers have used that are narrow band but invoked nonlinear lumped-parameter models account for relationship between pressure. There has been little attempt, however, deal with data both reflective nonlinearities. In present study, we collected such from mice. To interpret these data, first developed a time-domain approximation widely model impedance. We then extended this include resistive elastic terms. found term fit better than or resistance when amplitudes were large. This may be useful detecting overinflation lung during ventilation.