Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells.
作者： Ajay Goel , C.Richard Boland , Dharam P Chauhan
DOI: 10.1016/S0304-3835(01)00655-3
关键词:
摘要: Curcumin, a major yellow pigment and active component of turmeric, has been shown to possess anti-inflammatory anti-cancer activities. Cyclooxygenase (COX)-2 plays an important role in colon carcinogenesis. To investigate the effect curcumin on COX-2 expression, we treated HT-29 human cancer cells with various concentrations curcumin. Curcumin inhibited cell growth concentration- time-dependent manner. markedly mRNA protein expression COX-2, but not COX-1. These data suggest that non-toxic concentration significant vitro cells, specifically inhibits may have value as safe chemopreventive agent for cancer.
elsevier.com
wordpress.com 
cancerletters.info 参考文章(37)
Bernard W Stewart, Bernard W Stewart, D McGregor, Paul Kleihues, Principles of Chemoprevention ,(1996)
D.A. Kujubu, B.S. Fletcher, B.C. Varnum, R.W. Lim, H.R. Herschman, TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue Journal of Biological Chemistry. ,vol. 266, pp. 12866- 12872 ,(1991) , 10.1016/S0021-9258(18)98774-0
J K Gierse, S D Hauser, D P Creely, C Koboldt, S H Rangwala, P C Isakson, K Seibert, Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase Biochemical Journal. ,vol. 305, pp. 479- 484 ,(1995) , 10.1042/BJ3050479
E.A. Meade, W.L. Smith, D.L. DeWitt, Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. Journal of Biological Chemistry. ,vol. 268, pp. 6610- 6614 ,(1993) , 10.1016/S0021-9258(18)53294-4
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Yu Shyr, Jason D. Morrow, Robert J. Coffey, Robert J. Coffey, Rebecca Chinery, R. Daniel Beauchamp, Susan C. Kirkland, Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells. Cancer Research. ,vol. 58, pp. 2323- 2327 ,(1998)
Robert C. Smart, Ching-Quo Wong, Mou-Tuan Huang, Allan H. Conney, Inhibitory Effect of Curcumin, Chlorogenic Acid, Caffeic Acid, and Ferulic Acid on Tumor Promotion in Mouse Skin by 12-O-Tetradecanoylphorbol-13-acetate Cancer Research. ,vol. 48, pp. 5941- 5946 ,(1988)
Lee S. Simon, Biologic effects of nonsteroidal anti-inflammatory drugs. Current Opinion in Rheumatology. ,vol. 9, pp. 178- 182 ,(1997) , 10.1097/00002281-199705000-00002
Waun KI Hong, Scott M. Lippman, Loretta M. Itri, Daniel D. Karp, Jin S. Lee, Robert M. Byers, Stimson P. Schantz, Alan M. Kramer, Reuben Lotan, Lester J. Peters, Isaiah W. Dimery, Barry W. Brown, Helmuth Goepfert, Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck. The New England Journal of Medicine. ,vol. 323, pp. 795- 801 ,(1990) , 10.1056/NEJM199009203231205
Chieko Yokoyama, Toshiyuki Takai, Tadashi Tanabe, Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence FEBS Letters. ,vol. 231, pp. 347- 351 ,(1988) , 10.1016/0014-5793(88)80847-0