Cardiac muscle regeneration using mesenchymal stem cells

作者: Mark F. Pittenger , Alastair Morgan Mackay , Bradley J. Martin , Stephen L. Gordon

DOI:

关键词:

摘要: Disclosed is a method for producing cardiomyocytes in vivo by administering to the heart of an individual cardiomyocyte amount mesenchymal stem cells. These cells can be administered as liquid injectible or preparation matrix which becomes solid semi-solid. The genetically modified enhance myocardial differentiation and integration. Also disclosed replacing ex valve implantation.

参考文章(39)
Biology of endothelial cells Martinus Nijhoff Publishers , Distributors for the United States and Canada, Kluwer Boston. ,(1984) , 10.1007/978-1-4613-2825-4
Stephen E. Haynesworth, Arnold I. Caplan, Stanton L. Gerson, Transduced mesenchymal stem cells Biotechnology Advances. ,vol. 15, ,(1993)
Mark Waer, Michel Vandeputte, Y Lin, Natural killer cell- and macrophage-mediated rejection of concordant xenografts in the absence of T and B cell responses. Journal of Immunology. ,vol. 158, pp. 5658- 5667 ,(1997)
Theresa A. Deisher, Deborah L. Thompson, Emma E. Moore, Tamara L. Robertson, Birgit Hanson, Karen D. Lum, Cardiac-derived stem cells IDrugs : the investigational drugs journal. ,vol. 3, pp. 649- ,(1999)
J. Michael Sorrell, Arnold I. Caplan, Multilayer skin or dermal equivalent having a layer containing mesenchymal stem cells Delphion Inc., www.delphion.com. ,(1997)
Catherine M. Verfaillie, Leo T. Furcht, Morayma Reyes, Multipotent adult stem cells and methods for isolation ,(2000)
Richard J. Bucala, Anthony Cerami, Blood-borne mesenchymal cells ,(1995)
Darwin J Prockop, Joseph Kulkosky, Michael D O'hara, Dennis B Leeper, Donald Phinney, Alexander Laptev, Jose Caro, Ruth F Pereira, Isolated stromal cells and methods of using the same ,(1996)
Gene C. Kopen, Vanessa Ragaglia, William F. Righter, Joseph Wagner, Tony W. Ho, W. Joseph Herring, J. Lynn Rutkowski, Cell populations which co-express CD49c and CD90 ,(2002)
Stephen E. Haynesworth, Arnold I. Caplan, Human mesenchymal stem cells ,(1994)