International Prognostic Scoring System–independent cytogenetic risk categorization in primary myelofibrosis
作者： Kebede Hussein , Animesh D. Pardanani , Daniel L. Van Dyke , Curtis A. Hanson , Ayalew Tefferi
DOI: 10.1182/BLOOD-2009-08-240135
关键词:
摘要: Among 200 patients with primary myelofibrosis, karyotype at diagnosis was abnormal in 83 (42%). To assess their individual prognostic impact, specific cytogenetic abnormalities more than or equal to 5 informative cases were identified and the rest grouped separately as "other abnormalities." Median survival sole +9 (n = 6), 20q- 21), 13q- 8), normal 117), abnormalities" 28), complex 13), +8 7) "not reached," 112, 105, 80, 46, 34, 28 months, respectively (P .01). Accordingly, 4 risk groups considered: (1) favorable (sole +9, 20q-, 13q-), (2) normal, (3) unfavorable (complex +8), (4) Multivariable analysis confirmed International Prognostic Scoring System (IPSS)-independent value of both 4-way 2-way (ie, favorable/normal vs unfavorable/other abnormalities; IPSS-adjusted hazard ratio 0.37; 95% confidence interval, 0.24-0.58) categorization < The ability prognostically dissect a IPSS category has major therapeutic implications.
ashpublications.org
elsevier.com
bloodjournal.org参考文章(18)
Peter Greenberg, Christopher Cox, Michelle M. LeBeau, Pierre Fenaux, Pierre Morel, Guillermo Sanz, Miguel Sanz, Teresa Vallespi, Terry Hamblin, David Oscier, Kazuma Ohyashiki, Keisuke Toyama, Carlo Aul, Ghulam Mufti, John Bennett, International Scoring System for Evaluating Prognosis in Myelodysplastic Syndromes Blood. ,vol. 89, pp. 2079- 2088 ,(1997) , 10.1182/BLOOD.V89.6.2079
J. T. Reilly, J. A. Snowden, R. L. Spearing, P. M. Fitzgerald, N. Jones, A. Watmore, A. Potter, Cytogenetic abnormalities and their prognostic significance in idiopathic myelofibrosis: a study of 106 cases British Journal of Haematology. ,vol. 98, pp. 96- 102 ,(1997) , 10.1046/J.1365-2141.1997.1722990.X
Daniella M.B. Kerbauy, Theodore A. Gooley, George E. Sale, Mary E.D. Flowers, Kristine C. Doney, George E. Georges, Joanne E. Greene, Michael Linenberger, Effie Petersdorf, Brenda M. Sandmaier, Bart L. Scott, Mohamed Sorror, Derek L. Stirewalt, F. Marc Stewart, Robert P. Witherspoon, Rainer Storb, Frederick R. Appelbaum, H. Joachim Deeg, Hematopoietic Cell Transplantation as Curative Therapy for Idiopathic Myelofibrosis, Advanced Polycythemia Vera, and Essential Thrombocythemia Biology of Blood and Marrow Transplantation. ,vol. 13, pp. 355- 365 ,(2007) , 10.1016/J.BBMT.2006.11.004
A Tefferi, T L Lasho, J Huang, C Finke, R A Mesa, C Y Li, W Wu, C A Hanson, A Pardanani, Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival Leukemia. ,vol. 22, pp. 756- 761 ,(2008) , 10.1038/SJ.LEU.2405097
Ayalew Tefferi, Molecular drug targets in myeloproliferative neoplasms: mutant ABL1, JAK2, MPL, KIT, PDGFRA, PDGFRB and FGFR1 Journal of Cellular and Molecular Medicine. ,vol. 13, pp. 215- 237 ,(2009) , 10.1111/J.1582-4934.2008.00559.X
Constantine S. Tam, Lynne V. Abruzzo, Katherine I. Lin, Jorge Cortes, Alice Lynn, Michael J. Keating, Deborah A. Thomas, Sherry Pierce, Hagop Kantarjian, Srdan Verstovsek, The role of cytogenetic abnormalities as a prognostic marker in primary myelofibrosis: applicability at the time of diagnosis and later during disease course Blood. ,vol. 113, pp. 4171- 4178 ,(2009) , 10.1182/BLOOD-2008-09-178541
Clara D. Bloomfield, Cynthia Shuma, Linda Regal, Preben P. Philip, Dieter K. Hossfeld, Anne M. Hagemeijer, O. Margaret Garson, Bruce A. Peterson, Masaharu Sakurai, Giuliana Alimena, Roland Berger, Janet D. Rowley, Tapani Ruutu, Felix Mitelman, Gordon W. Dewald, John Swansbury, Long-term survival of patients with acute myeloid leukemia: a third follow-up of the Fourth International Workshop on Chromosomes in Leukemia. Cancer. ,vol. 80, pp. 2191- 2198 ,(1997) , 10.1002/(SICI)1097-0142(19971201)80:11+<2191::AID-CNCR5>3.0.CO;2-L
Kathrin Strasser-Weippl, Michael Steurer, Mathias Kees, Florian Augustin, Alexandar Tzankov, Stephan Dirnhofer, Michael Fiegl, Heinz Gisslinger, Niklas Zojer, Heinz Ludwig, Chromosome 7 deletions are associated with unfavorable prognosis in myelofibrosis with myeloid metaplasia Blood. ,vol. 105, pp. 4146- 4146 ,(2005) , 10.1182/BLOOD-2004-11-4319
Ayalew Tefferi, Ruben A. Mesa, Georgene Schroeder, Curtis A. Hanson, Chin-Yang Li, Gordon W. Dewald, Cytogenetic findings and their clinical relevance in myelofibrosis with myeloid metaplasia British Journal of Haematology. ,vol. 113, pp. 763- 771 ,(2001) , 10.1046/J.1365-2141.2001.02796.X
Sergio Siragusa, Francesco Passamonti, Francisco Cervantes, Ayalew Tefferi, Survival in young patients with intermediate- / high-risk myelofibrosis: estimates derived from databases for non transplant patients. American Journal of Hematology. ,vol. 84, pp. 140- 143 ,(2009) , 10.1002/AJH.21342