Chemotherapy of surra in horses and mules with diminazene aceturate

摘要: During June-July 2000, an outbreak of surra occurred on equine breeding farm in Khonkaen Province, Thailand. Forty-two percent pregnant mares aborted or gave stillbirth and 40% (19/47) horses 10% (1/10) mules died from surra. In August 2000 Trypanosoma evansi were detected the remaining animals (28 nine mules) by blood smear and/or haematocrit centrifuge technique. All treated with diminazene aceturate at 3.5 mg/kg body weight intramuscular injection days 0 41 study. Blood samples eight randomly selected collected 0, 1 once a week until day 56 examined for T. various parasitological techniques. The sera tested antibodies against using indirect enzyme linked immunosorbent assay (ELISA).The results revealed that appeared to be effective first treatment infected evansi. Parasites cleared peripheral 7 14. Thereafter number positive increased. After second treatment, 50% 25% still 24 h after demonstrating had no protective effect. Mild severe toxicity was seen injection.