Treatment of acute HIV-1 infection: are we getting there?

摘要: Purpose of review Treatment primary HIV-1 infection may alter the natural history and delay need for chronic antiretroviral therapy; it also be a public health measure. We discuss results therapeutic trials cohort studies, occurrence transmitted drug resistance, recent findings in terms immunopathogenesis decay viral reservoirs. Recent Events at time are understood to set scene persistence immunologic damage immune activation, with rapid onslaught primarily on memory CD4+ T cells mucosal effector sites. The initiation therapy has been associated high degree undetectable viremia compliant patients substantial reservoirs peripheral blood. reconstitution gut level, however, does not appear comparable that Summary insights into long-term consequences early burst replication – together onward transmission, possibility important steps helping design future strategies an era intense vaccine development.