Inferior frontal and insular cortical thinning is related to dysfunctional brain activation/deactivation during working memory task in schizophrenic patients

摘要: Although working memory is known to be impaired in schizophrenia the anatomical and functional relationships underlying this deficit remain elucidated. A combined imaging approach involving structural magnetic resonance techniques was used, applying independent component analysis surface-based morphometry 14 patients with healthy controls. Neurocognitive functioning assessed by a neuropsychological test battery that measured executive function. It hypothesized dysfunctional connectivity related abnormalities. Patients showed cortical thinning left inferior frontal gyrus insula, which explained 57% of blood oxygenation level-dependent signal magnitude central network (lateral prefrontal parietal cortex) over-activation default mode (anterior posterior cingulate) deactivation. No structure-function relationship emerged control group. The study provides evidence suggest activation/deactivation patterns may terms gray matter deficits.