Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study
作者： Rebecca C Richmond , Emma L Anderson , Hassan S Dashti , Samuel E Jones , Jacqueline M Lane
DOI: 10.1136/BMJ.L2327
关键词:
摘要: Abstract Objective To examine whether sleep traits have a causal effect on risk of breast cancer. Design Mendelian randomisation study. Setting UK Biobank prospective cohort study and Breast Cancer Association Consortium (BCAC) case-control genome-wide association Participants 156 848 women in the multivariable regression one sample mendelian (MR) analysis (7784 with cancer diagnosis) 122 977 cases 105 974 controls from BCAC two MR analysis. Exposures Self reported chronotype (morning or evening preference), insomnia symptoms, duration regression, genetic variants robustly associated these traits. Main outcome measure diagnosis. Results In using data incidence, morning preference was inversely (hazard ratio 0.95, 95% confidence interval 0.93 to 0.98 per category increase), whereas there little evidence for an between symptoms. Using 341 single nucleotide polymorphisms (SNPs) chronotype, 91 SNPs duration, 57 provided some supportive protective (0.85, 0.70, 1.03 increase) but imprecise estimates Two supported findings (inverse variance weighted odds 0.88, 0.82 adverse increased (1.19, 1.02 1.39 hour (both oestrogen receptor positive negative), symptoms inconsistent. were largely robust sensitivity analyses accounting horizontal pleiotropy. Conclusions Findings showed consistent suggestive risk.
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