摘要: Hepatitis E is an emerging disease in resource-poor regions of the world. It estimated that about 2 billion people live areas endemic for this disease. The inability to reproducibly culture hepatitis virus makes it impossible develop traditional or inactivated vaccines. However, significant progress has been made developing and testing recombinant subunit vaccines based on viral capsid protein. This review summarizes these efforts.
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Hong-Ying Gang, Hong-Zhao Li, Yan-Bing Ma, Qiang-Ming Sun, Xiao Liu, Chang-Bai Dai, Mao-Sheng Sun, Production in Pichia pastoris and characterization of genetic engineered chimeric HBV/HEV virus-like particles. Chinese Medical Sciences Journal. ,vol. 19, pp. 78- 83 ,(2004)
J He, A W Tam, P O Yarbough, G R Reyes, M Carl, Expression and diagnostic utility of hepatitis E virus putative structural proteins expressed in insect cells. Journal of Clinical Microbiology. ,vol. 31, pp. 2167- 2173 ,(1993) , 10.1128/JCM.31.8.2167-2173.1993
Mohammad Sultan Khuroo, Saleem Kamili, Mohammad Yousuf Dar, Randolph Moecklii, Shahid Jameel, Hepatitis E and long-term antibody status The Lancet. ,vol. 341, pp. 1355- 1355 ,(1993) , 10.1016/0140-6736(93)90873-F
P O Yarbough, A W Tam, K E Fry, K Krawczynski, K A McCaustland, D W Bradley, G R Reyes, Hepatitis E virus: identification of type-common epitopes. Journal of Virology. ,vol. 65, pp. 5790- 5797 ,(1991) , 10.1128/JVI.65.11.5790-5797.1991
J. P. Bryan, S. A. Tsarev, M. Iqbal, J. Ticehurst, S. Emerson, A. Ahmed, J. Duncan, A. Rauf Rafiqui, I. A. Malik, R. H. Purcell, L. J. Legters, Epidemic Hepatitis E In Pakistan: Patterns Of Serologic Response And Evidence That Antibody To Hepatitis E Virus Protects Against Disease The Journal of Infectious Diseases. ,vol. 170, pp. 517- 521 ,(1994) , 10.1093/INFDIS/170.3.517
M. O. Favorov, H. A. Fields, M. A. Purdy, T. L. Yashina, A. G. Aleksandrov, M. J. Alter, D. M. Yarasheva, D. W. Bradley, H. S. Margolis, Serologic identification of hepatitis E virus infections in epidemic and endemic settings. Journal of Medical Virology. ,vol. 36, pp. 246- 250 ,(1992) , 10.1002/JMV.1890360403
Masahiro Niikura, Shiki Takamura, Gisen Kim, Satoru Kawai, Masayuki Saijo, Shigeru Morikawa, Ichiro Kurane, Tian-Cheng Li, Naokazu Takeda, Yasuhiro Yasutomi, Chimeric Recombinant Hepatitis E Virus-like Particles as an Oral Vaccine Vehicle Presenting Foreign Epitopes Virology. ,vol. 293, pp. 273- 280 ,(2002) , 10.1006/VIRO.2001.1240
Saeed S. Hamid, Muslim Atiq, Farooq Shehzad, Aneela Yasmeen, Tayyabun Nissa, Abdul Salam, Anwar Siddiqui, Wasim Jafri, HEPATITIS E VIRUS SUPERINFECTION IN PATIENTS WITH CHRONIC LIVER DISEASE Hepatology. ,vol. 36, pp. 474- 478 ,(2002) , 10.1053/JHEP.2002.34856
Fan Li, Joseph Torresi, Stephen A. Locarnini, Hui Zhuang, Wanfu Zhu, Xiaoxia Guo, David A. Anderson, Amino-terminal epitopes are exposed when full-length open reading frame 2 of hepatitis E virus is expressed in Escherichia coli, but carboxy-terminal epitopes are masked Journal of Medical Virology. ,vol. 52, pp. 289- 300 ,(1997) , 10.1002/(SICI)1096-9071(199707)52:3<289::AID-JMV10>3.0.CO;2-E
Albert W Tam, Robert White, Patrice O Yarbough, Brendan J Murphy, C.Patrick McAtee, Robert E Lanford, Thomas R Fuerst, In Vitro Infection and Replication of Hepatitis E Virus in Primary Cynomolgus Macaque Hepatocytes Virology. ,vol. 238, pp. 94- 102 ,(1997) , 10.1006/VIRO.1997.8817