Low-molecular weight forms of cyclin E differentiate ovarian carcinoma from cells of mesothelial origin and are associated with poor survival in ovarian carcinoma

摘要: BACKGROUND. The authors recently reported on the role of cyclin E in differentiating ovarian/primary peritoneal carcinoma from malignant mesothelioma using gene expression arrays. In current study, they analyzed low-molecular weight (LMW) forms ovarian carcinoma, mesothelioma, and benign reactive effusions. METHODS. Cyclin protein was 98 effusions (72 carcinomas, 14 mesotheliomas, 12 specimens) immunoblotting. Sixty-two were studied further for immunohistochemistry. The correlations between clinical parameters, including chemotherapy response, analyzed. RESULTS. LMW identified 54 72 (75%) compared with 1 (7%) (8%) (P < .001). Their presence associated a higher percentage E-positive cells = .001) increased staining intensity LMW correlated shorter overall survival .021) progression-free .020). immunohistochemistry .026). No association response observed. CONCLUSIONS. LMW differentiated mesothelial not although it may be marker aggressive disease patients metastatic carcinoma. Cancer 2007. © 2007 American Society.