Mitophagy, metabolism, and cell fate.
作者： Lorena Esteban-Martínez , Elena Sierra-Filardi , Patricia Boya
DOI: 10.1080/23723556.2017.1353854
关键词:
摘要: Mitophagy is the process by which cells eliminate damaged or superfluous mitochondria degrading them within lysosomes. We show that during development, selective removal of autophagy induces a metabolic shift toward glycolysis essential for differentiation several cell types. These findings suggest potential applications cell-fate manipulation strategies targeting mitophagy.
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