Association of polycystic ovary syndrome or anovulatory infertility with offspring psychiatric and mild neurodevelopmental disorders: a Finnish population-based cohort study.

摘要: Study question Is maternal polycystic ovary syndrome (PCOS) associated with increased risks for a broad spectrum of psychiatric and mild neurodevelopmental disorders in offspring? Summary answer Maternal PCOS and/or anovulatory infertility is independently, jointly obesity, perinatal problems, cesarean delivery gestational diabetes, offspring almost all groups onset childhood or adolescence. What known already was previously autism disorder, attention-deficit/hyperactivity possibly developmental delay offspring. Few studies have investigated the association between other design, size, duration This population-based cohort study Finland including live births 1996 2014 (n = 1 105 997). After excluding to mothers symptoms similar PCOS, total 097 753 by 590 939 remained. Children were followed up until 31 December 2018, i.e. age 22 years. Participants/materials, setting, methods National registries used link data included their mothers. Data from 24 682 (2.2%) children born compared 073 071 (97.8%) without PCOS. Cox proportional hazards modeling evaluate hazard ratio (HR) 95% CI risk neuropsychiatric relation Stratified analyses performed test independent role joint effects delivery, diabetes use fertility treatment. The analysis adjusted age, country birth, marriage status at smoking, parity, disorders, prescription psychotropic N05/N06 during pregnancy systemic inflammatory diseases when applicable. Main results chance A 409 (9.8%) diagnosed disorder. Firstly, any diagnosis (HR 1.32; 1.27-1.38) Particularly, sleeping 1.46; 1.27-1.67), conduct 1.42; 1.33-1.52), tic 1.21-1.68), intellectual disabilities 1.41; 1.24-1.60), disorder 1.40; 1.26-1.57), specific 1.37; 1.30-1.43), eating 1.36; 1.15-1.61), anxiety 1.33; 1.26-1.41), mood 1.27; 1.18-1.35) behavioral emotional (ICD-10 F98, HR 1.49; 1.39-1.59). In short, there no significant difference sexes. robust restricting first-born purchase medication. Secondly, stratified according BMI showed that normal-weight 1.20; 1.09-1.32), markedly higher those severely obese 2.11; 1.76-2.53) When still 1.28; 1.22-1.34) However, an additional increase observed combination problems 1.99; 1.84-2.16). Likewise, cases 1.30; 1.25-1.36), 1.29; 1.23-1.35) treatment 1.31; 1.25-1.36) did not eliminate associations. Limitations, reasons caution register-based prevalence lower than reported, suggesting this may capture most severe cases. To combine as exposure might introduce diagnostic bias. It feasible distinguish subtypes Furthermore, familial factors confound available birth 2004-2014 only information on weight gain. Wider implications findings provides further evidence infertility, independently implies range adverse neurodevelopment. These potentially help counseling managing pregnancies. funding/competing interest(s) supported research funding Shandong University Karolinska Institute (SDU-KI-2019-08 X.C C.L.), THL Finnish Health Welfare: Drug project [M.G.], Swedish Research Council [2014-10171 C.L.], regional agreement medical training clinical (ALF) Stockholm County [SLL20170292 Brain Foundation [FO2018-0141 FO2019-0201 C.L.]. X.C. China Scholarship her Institute. L.K. his PhD authors competing interests disclose. Trial registration number N/A.