Induced Chromosomal Exchange Directs the Segregation of Recombinant Chromatids in Mitosis of Drosophila
作者： Sergio Pimpinelli , Kent G. Golic , Kelly J. Beumer
DOI: 10.1093/GENETICS/150.1.173
关键词:
摘要: In meiosis, the segregation of chromosomes at reductional division is accomplished by first linking homologs together. Genetic exchange generates bivalents that direct regular chromosome segregation. We show genetic in mitosis also and these mitotic After FLP-mediated homologous recombination G2 cell cycle, recombinant chromatids consistently segregate away from each other (x segregation). This pattern applies to between heterologs. Most, or all, cases non-x are result G1. Cytological evidence presented confirms existence this Our results implicate sister chromatid cohesion maintenance bivalent. The can be altered providing an additional FRT a more proximal site on one chromosome. propose occurs site, allowing allowed recovery reciprocal translocations following heterologous recombination. observation generate bivalent divisions provides support for simple evolutionary relationship meiosis.
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