The use of bacteriophages to biocontrol oral biofilms

摘要: Infections induced by oral biofilms include caries, as well periodontal, and peri-implant disease, may influence quality of life, systemic health, expenditure. As bacterial are highly resistant resilient to conventional antibacterial therapy, it has been difficult combat these infections. An innovative alternative the biocontrol could be use bacteriophages or phages, viruses bacteria, which specific, non-toxic, self-proliferating, can penetrate into biofilms. Phages for Actinomyces naeslundii, Aggregatibacter actinomycetemcomitans, Enterococcus faecalis, Fusobacterium nucleatum, Lactobacillus spp., Neisseria Streptococcus Veillonella spp. have isolated characterised. Recombinant phage enzymes (lysins) shown lyse A. naeslundii However, only a tiny fraction available phages their lysins explored so far. The unique properties make them promising but challenging antimicrobials. genetics biology further in order determine most effective way applying them. Studying effect on multispecies should pave microbiota engineering microbiota-based therapy.