Overexpression of bromodomain factor 3 in Trypanosoma cruzi (TcBDF3) affects differentiation of the parasite and protects it against bromodomain inhibitors.
作者： Victoria Lucia Alonso , Carla Ritagliati , Pamela Cribb , Julia Alejandra Cricco , Esteban Carlos Serra
DOI: 10.1111/FEBS.13719
关键词:
摘要: The bromodomain is the only protein domain known to bind acetylated lysine. In last few years many inhibitors have been developed in order treat diseases such as cancer caused by aberrant acetylation of lysine residues. We previously characterized Trypanosoma cruzi factor 3 (TcBDF3), a with an atypical localization that binds α-tubulin. present work we show parasites overexpressing TcBDF3 exhibit altered differentiation patterns and are less susceptible treatment inhibitors. also demonstrate recombinant able these vitro concentration-dependant manner. parallel, overexpression mutated version negatively affects growth epimastigotes. Recent results, including ones presented here, suggest can be conceived new type anti-parasitic drug against trypanosomiasis.
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