Regulatory mechanisms that govern nicotinic synapse formation in neurons

作者: Madelaine M. Rosenberg , Rachel C. Blitzblau , Douglas P. Olsen , Michele H. Jacob

DOI: 10.1002/NEU.10112

关键词:

摘要: Individual cholinoceptive neurons express high levels of different neuronal nicotinic acetylcholine receptor (nAChR) subtypes, and target them to the appropriate synaptic regions for proper function. This review focuses on intercellular intracellular processes that regulate nAChR expression in vertebrate peripheral nervous system (PNS) central (CNS) neurons. Specifically, we discuss cellular molecular mechanisms govern induction maintenance expression-innervation, tissue interactions, soluble factors, activity. We define regulatory principles interneuronal synapse differentiation have emerged from these studies. also players nAChRs surface membrane synapse.

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