Vascular aging and preclinical target organ damage in community-dwelling elderly: the Northern Shanghai Study.

摘要: OBJECTIVES Vascular aging represents a mediating step between risk factors and cardiovascular events, preclinical target organ damage (TOD) integrates the cumulative effect of factors. This study is aimed at relationships vascular TOD. METHODS Two thousand ninety-eight participants (45.52% men, aged 71.3 ± 6.1 years) were recruited from June 2014 to 2017 communities in northern Shanghai area. Preclinical TOD was assessed all participants. Other clinical information obtained by standard questionnaire. Healthy (HVA) defined as absence hypertension relatively normal carotid-femoral PWV based on participants' age blood pressure. We fitted logistic regression models assess probability non-HVA association with RESULTS Six hundred forty-two (30.6%) elderly had HVA, prevalence HVA decreased 30.84% (aged 65-66) 20.72% ≥75). Increased age, increased SBP, metabolic syndrome, BMI family history premature disease (CVD) significantly associated accelerated (P = 0.031 P < 0.001). After multivariate adjustments, left ventricular diastolic dysfunction (LVDD; OR (95% CI) 1.83 (1.23, 2.71), P = 0.003), hypertrophy (LVH; 1.97 (1.54, 2.51), P < 0.001) micro-albuminuria (MAU; 1.66 (1.35, 2.03), CONCLUSION Management pressure profile may help alleviate LVH, LVDD MAU, which serve potential reverse cardiac renal