Cholinesterases, Esterases and Lipases

作者: R.A. OOSTERBAAN , H.S. JANSZ

DOI: 10.1016/B978-1-4831-9710-4.50008-8

关键词:

摘要: Publisher Summary The enzymes, cholinesterases, esterases, and lipases, catalyze the hydrolysis of carboxyl esters. It has been shown that enzymatic ester cleavage is governed by a mechanism, which similar for different enzymes. Evidence derived from studies on kinetics interaction these enzymes with substrates inhibitors specifically chemical analysis active site. similarity in mechanism might be because presence common or related site esterases. This chapter presents information their inhibitors, contributes to an understanding molecular basis general hydrolysis. further data relevant substrate specificities individual Enzymes hydrolyze choline esters are usually sub-divided into acetyl-, propionyl-, butyryl- benzoyl-cholinesterases depending hydrolyzed at highest rate. ability act undissolved proposed differentiate lipases other carboxylesterases like ali-esterases only solution.

参考文章(275)
William M. Connors, Alexander Pihl, Alexander L. Dounce, Elmer Stotz, Purification of liver esterase. Journal of Biological Chemistry. ,vol. 184, pp. 29- 36 ,(1950) , 10.1016/S0021-9258(19)51119-X
E. D. Wills, The effect of anionic detergents and some related compounds on enzymes Biochemical Journal. ,vol. 57, pp. 109- 120 ,(1954) , 10.1042/BJ0570109
F.H. Mattson, E.S. Lutton, The Specific Distribution of Fatty Acids in the Glycerides of Animal and Vegetable Fats Journal of Biological Chemistry. ,vol. 233, pp. 868- 871 ,(1958) , 10.1016/S0021-9258(18)64670-8
C.G. King, H.H.R. Weber, SPECIFICITY AND INHIBITION CHARACTERISTICS OF LIVER ESTERASE AND PANCREAS LIPASE Journal of Biological Chemistry. ,vol. 108, pp. 131- 139 ,(1935) , 10.1016/S0021-9258(18)75317-9
Edward D. Korn, Thomas W. Quigley, Lipoprotein lipase of chicken adipose tissue. Journal of Biological Chemistry. ,vol. 226, pp. 833- 839 ,(1957) , 10.1016/S0021-9258(18)70867-3
Norwood K. Schaffer, Stephen C. May, William H. Summerson, Serine phosphoric acid from diisopropylphosphoryl chymotrypsin. Journal of Biological Chemistry. ,vol. 202, pp. 67- 76 ,(1953) , 10.1016/S0021-9258(19)57107-1
L. A. Mounter, V. P. Whittaker, The hydrolysis of esters of phenol by cholinesterases and other esterases Biochemical Journal. ,vol. 54, pp. 551- 559 ,(1953) , 10.1042/BJ0540551
H. Claire Lawler, Turnover time of acetylcholinesterase. Journal of Biological Chemistry. ,vol. 236, pp. 2296- 2301 ,(1961) , 10.1016/S0021-9258(18)64074-8
C.E. McDonald, A.K. Balls, Analogues of acetyl chymotrypsin. Journal of Biological Chemistry. ,vol. 227, pp. 727- 736 ,(1957) , 10.1016/S0021-9258(18)70753-9