Regulation of protein synthesis by insulin through IRS-1.
作者： Raul Mendez , Gavin Welsh , Miranda Kleijn , Martin G. Myers , Morris F. White
DOI: 10.1007/978-3-642-56688-2_3
关键词:
摘要: Most regulatory mechanisms for the overall rate of protein synthesis described to date involve initiation phase, which is catalyzed by factors (eIF1; Merrick and Hershey 1996; Rhoads 1999). Protein occurs in a series discrete steps. A ternary complex eIF2•GTP•Met-tRNAi binds 40 S ribosomal subunit eIF3 form 43 complex. The eIF4 plus poly(A)-binding collectively recognize 5′-terminal cap or 3′-terminal poly(A) tract mRNA, unwind its secondary structure, transfer it complex, resulting 48 Scanning first codon good sequence context requires ATP hydrolysis eIF4A presence eIF1 eIF1A (Pestova et al. 1998). Then, eIF5 stimulates GTP eIF2, after are replaced 60 80 released eIF2-GDP recycled eIF2-GTP guanine nucleotide exchange factor eIF2B. elongator aminoacyl-tRNA brought A-site eEF1, followed peptide bond translocation eEF2
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