Saccharomyces boulardii CNCM I-745 Improves Intestinal Enzyme Function: A Trophic Effects Review.

摘要: Several properties of the probiotic medicinal yeast Saccharomyces boulardii CNCM I-745 contribute to its efficacy prevent or treat diarrhoea. Besides immunologic effects, pathogen-binding and anti-toxin as well positive effects on microbiota, S also has pronounced digestive enzymes brush border membrane, known trophic effects. The latter are focus this review. Literature been reviewed after searching Medline PMC databases. All relevant non-clinical clinical studies summarized. S. synthesizes secretes polyamines, which have a role in cell proliferation differentiation. administration polyamines enhances expression intestinal nutrient uptake transporters. signalling mechanisms leading enzyme activation not fully understood. However, direct nucleic acid-binding capacity with regulatory impact. induces via mitogen-activated protein kinase pathway. In addition, phosphatidylinositol-3 (PI3K) pathway reported. As an additional effect, certain enzymes, enhance acquisition for host. increased availability seems be one by counteracts diarrhoea; however, people deficiencies may profit from administration. More needed understand yeast.