Innate Immunity Acts as the Major Regulator in Talaromyces marneffei Coinfected AIDS Patients: Cytokine Profile Surveillance During Initial 6-Month Antifungal Therapy.

摘要: Background Talaromycosis caused by Talaromyces marneffei infection is a fatal systemic mycosis in immunosuppressed individuals, such as patients with AIDS. Cytokines and immunocytes play central role against fungus infection. However, how the host immune system responds to treatment has not been reported date. Methods Forty-one coinfected AIDS were followed up, their cytokine profiles obtained at different antifungal stages, data on clinical features laboratory examinations collected. Correlation analysis was used identify factors associated immunity patients. Results Common diseases conditions of these 41 lymphadenopathy, hepatomegaly, splenomegaly. CD4+ T cells extremely low all them. Moreover, significant increases proinflammatory cytokines (IL-12, IL-17A, TNF-α, IFN-γ, IL-18, IL-1β), anti-inflammatory (IL-10), chemokines (IP-10) observed talaromycosis before (P < .05), comparing both healthy controls. The IL-6, IL-8, IL-7, IP-10, IL-1β reached peak levels 3 days after initial therapy, then gradually decreased. symptoms Furthermore, who died showed highest IL-1β, which 1.4- 164-fold higher than surviving Conclusions Our findings indicate that innate immune-cell-derived are critical for defense AIDS-associated infection; furthermore, excessive inflammatory poor outcomes.