Ecotoxicoproteomics: A decade of progress in our understanding of anthropogenic impact on the environment.

摘要: Anthropogenic pollutants are found worldwide. Their fate and effects on human ecosystem health must be appropriately monitored. Today, ecotoxicology is focused the development of new methods to assess impact pollutant toxicity living organisms ecosystems. In situ biomonitoring often uses sentinel animals for which, ideally, molecular biomarkers have been defined thanks which environmental quality can assessed. this context, high-throughput proteomics offer an attractive approach study early responses stressors. This used identify pathways, quantify more precisely novel biomarkers, draw possible adverse outcome pathways. review, we discuss major advances in ecotoxicoproteomics made over last decade present current state knowledge, emphasizing technological conceptual advancements that allowed breakthroughs field, aims "make our planet great again". SIGNIFICANCE: Ecotoxicoproteomics a protein-centric methodology useful could future applications as part chemical risk assessment monitoring. Ecotoxicology employing non-model with highly divergent phylogenetic backgrounds preserve functioning ecosystems overall range biological species supporting them. The classical workflow involves protein identification, functional annotation, extrapolation across species. Thus, it essential develop multi-omics approaches order unravel information construct most suitable databases identification pathway analysis Current instrumentation available software allow relevant combined transcriptomic/proteomic studies performed almost any review summarizes these illustrates how they implemented routine biomonitoring.