Extensive Homeostatic T Cell Phenotypic Variation within the Collaborative Cross
作者： Jessica B. Graham , Jessica L. Swarts , Michael Mooney , Gabrielle Choonoo , Sophia Jeng
DOI: 10.1016/J.CELREP.2017.10.093
关键词:
摘要: The Collaborative Cross (CC) is a panel of reproducible recombinant inbred mouse strains with high levels standing genetic variation, affording an unprecedented opportunity to perform experiments in small animal model containing controlled diversity while allowing for replicates. Here, we advance the utility this unique resource for immunology research because it allows both examination and dissection mechanisms behind adaptive immune states mice distinct defined makeups. This approach based on quantitative trait locus mapping: identifying genetically variant genome regions associated phenotypic variance traits interest. Furthermore, CC can be utilized development; have immunophenotypes properties, making them suitable particular diseases infections. describe variations cellular phenotypes across F1 crosses reveal loci responsible several phenotypes.
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