Gene therapy compositions for preventing and/or treating autoimmune diseases
作者： Sabrina Tarufo , Martinez Xavier Anguela , Tubert Maria Fatima Bosch
DOI:
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摘要: Gene therapy compositions for the prevention and/or treatment of autoimmune diseases. The present invention relates to vectors, preferably plasmids that comprise specific promoters, encode insulin-like growth factor I (IGF-I) or a functional biological equivalent thereof, which will be used prevent treat Type 1 Diabetes (DT1) other Moreover, comprises method preventing treating DT1 by means expression IGF-I, in hepatic cells. IGF-I was capable interrupting immune attack against pancreatic β cells, thereby loss cell mass and, consequently, maintaining normal levels circulating insulin.
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