Antigen-presenting cell-mimetic scaffolds and methods for making and using the same

摘要: Embodiments herein described provide antigen-presenting cell-mimetic scaffolds (APC-MS) and use of such to manipulating T-cells. More specifically, the are useful for promoting growth, division, differentiation, expansion, proliferation, activity, viability, exhaustion, anergy, quiescence, apoptosis, or death T-cells in various settings, e.g., vitro, ex vivo, vivo . further relate pharmaceutical compositions, kits, packages containing scaffolds. Additional embodiments methods making scaffolds, kits/packages. Also using and/or kits diagnosis therapy diseases as cancers, immunodeficiency disorders, autoimmune disorders.