Forty-one recent cases of invasive zygomycosis from a global clinical registry

摘要: Background Invasive zygomycosis accounts for a significant proportion of all invasive fungal diseases (IFD), but clinical data on the course and treatment response are limited. Patients methods Fungiscope-A Global Rare Fungal Infection Registry is an international university-based case registry that collects patients with rare IFD, using web-based electronic form at www.fungiscope.net. Results Forty-one from central Europe Asia were registered. The most common underlying conditions malignancies (n = 26; 63.4%), diabetes mellitus 7; 17.1%) solid organ transplantation 4; 9.8%). Diagnosis was made by culture in 28 (68.3%) histology 26 (63.4%). main sites infection lungs 24; 58.5%), soft tissues 8; 19.5%), rhino-sinu-orbital region 19.5%) brain 6; 14.6%). Disseminated more than one non-contiguous site seen six (14.6%). Mycocladus corymbifer frequently identified species 10, 24.4%). A favourable observed 23 (56.1%). Overall survival 51.2% 21). At diagnosis, four (9.8%) continuous antifungal prophylaxis itraconazole 1; 2.4%) or posaconazole 3; 7.3%). Initial targeted activity against zygomycetes administered to 34 (82.9%). Liposomal amphotericin B associated improved (P 0.012) rates 0.004). Conclusions Pathogen distribution and, consequently, drug susceptibility seem vary across different geographic regions. Furthermore, protection not absolute. Our findings indicate use liposomal as first-line diagnosed zygomycoses merits further investigation, preferably trial.