Prognostic value of the C-reactive protein/Albumin Ratio (CAR) in patients with operable soft tissue sarcoma

摘要: // Yao Liang 1, * , Wei Xiao Yuan-Xiang Guan Wang 1 Huo Ying Chen Cheng Fang Xing Zhang and Zhi-Wei Zhou Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Medicine, Guangzhou 510060, People’s Republic China Co-first authors Correspondence to: Zhou, email: zhouzhw@sysucc.org.cn Zhang, zhangxing@sysucc.org.cn Keywords: C-reactive protein; albumin; inflammation-based prognostic factors; soft tissue sarcoma; prognosis Received: July 19, 2017     Accepted: August 17, Published: September 18, 2017 ABSTRACT Background: The preoperative protein/Albumin ratio (CAR) is valuable predicting the patients with various types cancers. aim present study to investigate value CAR compare it other systemic inflammatory response markers sarcoma (STS). Methods: This retrospective included 206 STS. optimal cutoff was determined by receiver operating characteristic (ROC) analysis. impact clinicopathological features on overall survival (OS) disease-free (DFS) evaluated using univariate multivariate Cox regression analyses. Kaplan-Meier analyses were used groups classified CAR. Additionally, area under curve (AUC) predictive ability CAR, high-sensitivity modified Glasgow score (Hs-mGPS), neutrophil-lymphocyte (NLR) platelet-lymphocyte (PLR). Results: cut-off 0.1035 according ROC An increased (≥0.1035) significantly associated older age, larger tumor size, deep location, higher grade more advanced American Joint Committee (AJCC) stage (all P<0.05). Patients an elevated exhibited a shorter median time lower 5-year OS rate than those CAR<0.1035 (68.2 vs 115.8 months, P = 0.000; 44.6% 80.9%, 0.000, respectively). results analysis indicated that (Hazard (HR) 2.47, 95% confidence interval (CI) 1.47-4.14, 0.001) independent factor along (P<0.05). greater AUC (0.662) NLR PLR, but equal Hs-mGPS. Conclusions: STS exhibits superior compared established indices.