Identification of benzoxazole analogs as novel, S1P(3) sparing S1P(1) agonists.
作者： Guanghui Deng , Qinghua Meng , Qian Liu , Xuesong Xu , Qiongfeng Xu
DOI: 10.1016/J.BMCL.2012.04.095
关键词:
摘要: A novel series of benzoxazole-derived S1P(1) agonists were designed based on scaffold hopping molecular design strategy combined with computational approaches. Extensive SAR studies led to the discovery compound 17d as a selective agonist (over S1P(3)) high CNS penetration and favorable DMPK properties. also demonstrated in vivo pharmacological efficacy reduce blood lymphocyte mice after oral administration.
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