Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors
作者： Melissa Junttila
DOI:
关键词:
摘要: The present invention describes combination treatment comprising a PD- 1 axis binding antagonist and MEK inhibitor methods for use thereof, including of treating conditions where enhanced immunogenicity is desired such as increasing tumor the cancer.
glgoo.top参考文章(133)
Ron Firestein, Andrew Polson, Steven R. Leong, Wei-Ching Liang, Paul Polakis, Yan Wu, Anti-b7-h4 antibodies and immunoconjugates ,(2014)
Frederick M. Ausubel, Download Here, Short Protocols In Molecular Biology ,(2014)
R. A. Reisfeld, S. Sell, Monoclonal antibodies and cancer therapy UCLA symposium on molecular and cellular biology. Annual meeting. 14. pp. 33- 74 ,(1985)
Daniel J. Tenney, Kap-Sun Yeung, Juliang Zhu, Paul Michael Scola, Nishith Sanghvi, Li-Qiang Sun, Kenneth M. Boy, Martin Patrick Allen, David R. Langley, Eric P. Gillis, Michael S. Bowsher, Maude A. Poirier, Patrick C. Reid, Claudio Mapelli, Michael Matthew Miller, Eric Mull, Macrocyclic Inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 Protein/Protein Interactions ,(2014)
Ed Harlow, David Lane, Using Antibodies: A Laboratory Manual ,(1998)
Philip Shepherd, Christopher Dean, Monoclonal antibodies : a practical approach Oxford University Press. ,(2000)
David Catty, Antibodies :a practical approach : IRL Press. ,(1988)
Leo A. Paquette, Principles of modern heterocyclic chemistry ,(1968)
Solomon Langermann, Simultaneous inhibition of pd-l1/pd-l2 ,(2010)
Elvin A. Kabat, Sequences of proteins of immunological interest National Institutes of Health. ,(1991)