Angiogenesis inhibiting pyridazinamines

摘要: This invention concerns compounds of formula (I), the N-oxide forms, pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein X is CH or N; m 2 3 n 1, 3; 1 C-atoms CH2 groups (a) moiety, which may also contain one double bond, be substituted with C1-6alkyl, amino, aminocarbonyl, mono- di(C1-6alkyl)amino, C1-6alkyloxycarbonyl, C1-6alkylcarbonylamino, hydroxy C1-6alkyloxy; and/or said bridged C2-4alkanediyl; R1 hydrogen, C?1-6?alkyl, C1-6alkyloxy, C1-6alkylthio, Ar, ArNH-, C3-6cycloalkyl, hydroxymethyl benzyloxymethyl; R?2 R3? are taken together form a bivalent radical -CH=CH-CH=CH-; in case represents then L L?1, L2 L3?; N L?2 L3; L1? Ar-C?1-6?alkyloxy, Ar-oxy, Ar-thio, Ar-carbonylamino, di-Ar-methyloxy-, N-Ar-piperazinyl, N-Ar-homopiperazinyl, 2-benzimidazolinonyl, Ar-NR?4?-, Ar-Alk-NR4-, Ar-NR?4-Alk-NR5?- Het-NR4-; Ar-carbonyl, Ar-CH=CH-CH?2?-, naphtalenyl Het; L?3? C?1-6?alkyl two radicals selected from further optionally cyano hydroxy; 2,2-dimethyl-1,2,3,4-tetrahydro-naphtalenyl; 2,2-dimethyl-1H-2,3-dihydroindenyl; Ar-piperidinyl Ar-NR?4?-Alk-; R?4 R5? each independently hydrogen C?1-6?alkyl; Alk C1-6alkanediyl; their preparation, compositions containing them use as medicine.