A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors

作者: Youzhi Li , Jifeng Liu , Chiang Jia Li , Harry Rogoff , Wei Li

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摘要: The present invention relates to the use of a novel class cancer stem cell pathway (CSCP) inhibitors; methods using such compounds treat refractory, recurrent, or metastatic cancers; selective killing cells by with specific administration regimen; targeting inhibiting Stat3 pathway; in treatment conditions disorders mammal related aberrant activity; and processes for preparing intermediates thereof, pharmaceutical composition relevant compounds, these compounds.

参考文章(216)
Mustafa Benekli, Zheng Xia, Kathleen A. Donohue, Laurie A. Ford, Lynda A. Pixley, Maria R. Baer, Heinz Baumann, Meir Wetzler, Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival. Blood. ,vol. 99, pp. 252- 257 ,(2002) , 10.1182/BLOOD.V99.1.252
Yoshiyasu Aoki, Gerald M. Feldman, Giovanna Tosato, Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma Blood. ,vol. 101, pp. 1535- 1542 ,(2003) , 10.1182/BLOOD-2002-07-2130
C-L Chen, F-C Hsieh, J C Lieblein, J Brown, C Chan, J A Wallace, G Cheng, B M Hall, J Lin, Stat3 activation in human endometrial and cervical cancers. British Journal of Cancer. ,vol. 96, pp. 591- 599 ,(2007) , 10.1038/SJ.BJC.6603597
Li Li, Peter E. Shaw, Autocrine-mediated Activation of STAT3 Correlates with Cell Proliferation in Breast Carcinoma Lines Journal of Biological Chemistry. ,vol. 277, pp. 17397- 17405 ,(2002) , 10.1074/JBC.M109962200
Dario Ponti, Aurora Costa, Nadia Zaffaroni, Graziella Pratesi, Giovanna Petrangolini, Danila Coradini, Silvana Pilotti, Marco A. Pierotti, Maria Grazia Daidone, Isolation and In vitro Propagation of Tumorigenic Breast Cancer Cells with Stem/Progenitor Cell Properties Cancer Research. ,vol. 65, pp. 5506- 5511 ,(2005) , 10.1158/0008-5472.CAN-05-0626
Urban Fagerholm, Hans Lennernäs, EXPERIMENTAL ESTIMATION OF THE EFFECTIVE UNSTIRRED WATER LAYER THICKNESS IN THE HUMAN JEJUNUM, AND ITS IMPORTANCE IN ORAL-DRUG ABSORPTION European Journal of Pharmaceutical Sciences. ,vol. 3, pp. 247- 253 ,(1995) , 10.1016/0928-0987(95)00027-B
Nengxing Lin, Hiroshi Uchi, Yoichi Moroi, Noriko Fukiwake, Teruki Dainichi, Satoshi Takeuchi, Masakazu Takahara, Yating Tu, Masutaka Furue, Kazunori Urabe, Significance of the expression of phosphorylated signal transducer and activator of transcription-3, -Akt, and -cyclin D1 in angiosarcoma Journal of Dermatological Science. ,vol. 48, pp. 64- 66 ,(2007) , 10.1016/J.JDERMSCI.2007.06.010