Novel stat3 pathway inhibitors and cancer stem cell inhibitors

作者: Chiang Jia Li , Wei Li , Zhiwei Jiang , David Leggett

DOI:

关键词:

摘要: The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and cancer stem cell inhibitors; methods using such treat cancer; disorders in mammal related aberrent activity; pharmaceutical compositions containing compounds.

参考文章(244)
Anand C. Burman, Rama Mukherjee, Anu T. Singh, Manu Jaggi, Anti-cancer activity of carvedilol and its isomers ,(2002)
RM Weber-Nordt, C Egen, J Wehinger, W Ludwig, V Gouilleux-Gruart, R Mertelsmann, J Finke, Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood. ,vol. 88, pp. 809- 816 ,(1996) , 10.1182/BLOOD.V88.3.809.809
Mitosek-Szewczyk K, Rejdak K, Dobosz B, Bartosik-Psujek H, Stelmasiak Z, Kozioł-Montewka M, Belniak-Legieć E, Interleukin-6 concentration in serum and cerebrospinal fluid in multiple sclerosis patients. Medical Science Monitor. ,vol. 6, pp. 1104- 1108 ,(2000)
Rashmi Rawat, G. Jonah Rainey, Cynthia D. Thompson, Michelle R. Frazier-Jessen, Robert T. Brown, Richard P. Nordan, Constitutive activation of STAT3 is associated with the acquisition of an interleukin 6-independent phenotype by murine plasmacytomas and hybridomas. Blood. ,vol. 96, pp. 3514- 3521 ,(2000) , 10.1182/BLOOD.V96.10.3514
Stephen R. Byrn, Solid state chemistry of drugs ,(1982)
Sabine Gaisser, William Alexander Vousden, Rose Mary Sheridan, Ming-Qiang Zhang, Lesley Sarah Sheehan, Mohammed Nur-E-Alam, Rachel Edith Lill, Barrie Wilkinson, Christine Janet Martin, 21-deoxymacbecin analogues useful as antitumor agents ,(2006)
Azra J Alvi, Helen Clayton, Chirag Joshi, Tariq Enver, Alan Ashworth, Maria ad M Vivanco, Trevor C Dale, Matthew J Smalley, Functional and molecular characterisation of mammary side population cells Breast Cancer Research. ,vol. 5, pp. 1- 8 ,(2002) , 10.1186/BCR547
William Dalton, Richard Jove, Mark Jaroszeski, Richard A. Gilbert, Andrew D. Hamilton, Hua Yu, Richard Heller, Said Sebti, Inhibition of stat3 signal transduction for human cancer therapy ,(2000)