Inflammation and depression: why poststroke depression may be the norm and not the exception

摘要: Ischaemic stroke often precedes the appearance of clinical depression. Poststroke depression in turn influences prognostic outcome. In interest advancing our understanding biological mechanisms underlying development poststroke depression, this systematic review explores immunological processes driving inflammation-related cell death mood-related brain regions. Particular attention has been paid to cytokine-driven intrinsic apoptosis factors, including intracellular calcium, glutamate excitotoxicity and free radicals that appear following ischaemic damage whose presence significantly increases likelihood clinically defined