The c-jun Gene and its Role in Signal Transduction
作者： Michael Karin , Peter Angel , Robert Chiu , Tod Smeal , Elizabeth Allegretto
DOI: 10.1007/978-3-642-74197-5_33
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摘要: The family of protein kinases known collectively as kinase C (PKC) occupies a central role in cellular signal transduction (Nishizuka, 1984; 1988). PKCs are associated with the cell surface membrane and activated by diacylglycerols released result increased phosphoinositol turnover occurring after stimulation various receptors Berridge, 1985). In addition to these physiological activators, potently stimulated tumor promoting phorbol esters such 12-0-tetradecanoyl-phorbol-13-acetate (TPA). While many early events that occur immediately receptor occupancy lead activation PKC relatively well understood, stimulation, which responsible for long term effects on physiology, still rather nebulous.
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sci-hub.st 参考文章(53)
Nancy H. Colburn, Genes and Signal Transduction in Multistage Carcinogenesis ,(1989)
R J Imbra, M Karin, Metallothionein gene expression is regulated by serum factors and activators of protein kinase C Molecular and Cellular Biology. ,vol. 7, pp. 1358- 1363 ,(1987) , 10.1128/MCB.7.4.1358
J R Barber, I M Verma, Modification of fos proteins: phosphorylation of c-fos, but not v-fos, is stimulated by 12-tetradecanoyl-phorbol-13-acetate and serum Molecular and Cellular Biology. ,vol. 7, pp. 2201- 2211 ,(1987) , 10.1128/MCB.7.6.2201
P Angel, I Baumann, B Stein, H Delius, H J Rahmsdorf, P Herrlich, 12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region. Molecular and Cellular Biology. ,vol. 7, pp. 2256- 2266 ,(1987) , 10.1128/MCB.7.6.2256
Peter Angel, Masayoshi Imagawa, Robert Chiu, Bernd Stein, Richard J. Imbra, Hans J. Rahmsdorf, Carsten Jonat, Peter Herrlich, Michael Karin, Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor Cell. ,vol. 49, pp. 729- 739 ,(1987) , 10.1016/0092-8674(87)90611-8
Richard M. Myers, Donald C. Rio, Alan K. Robbins, Robert Tjian, SV40 gene expression is modulated by the cooperative binding of T antigen to DNA Cell. ,vol. 25, pp. 373- 384 ,(1981) , 10.1016/0092-8674(81)90056-8
Robert J. Distel, Hyo-Sung Ro, Barry S. Rosen, Douglas L. Groves, Bruce M. Spiegelman, Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos Cell. ,vol. 49, pp. 835- 844 ,(1987) , 10.1016/0092-8674(87)90621-0
Richard J. Imbra, Michael Karin, Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer. Nature. ,vol. 323, pp. 555- 558 ,(1986) , 10.1038/323555A0
I. Bernard Weinstein, Lih-Syng Lee, Paul B. Fisher, Alan Mufson, Hiroshi Yamasaki, Action of phorbol esters in cell culture: mimicry of transformation, altered differentiation, and effects on cell membranes. Journal of Supramolecular Structure. ,vol. 12, pp. 195- 208 ,(1979) , 10.1002/JSS.400120206
Wiebe Kruijer, Jonathan A. Cooper, Tony Hunter, Inder M. Verma, Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein Nature. ,vol. 312, pp. 711- 716 ,(1984) , 10.1038/312711A0